Shipping is the world's oldest sharing economy and is conducted in a self-organizing manner. Shipping is capital, energy, and information intensive, and with the growing impact of digitalization and climate change, there is a need to rethink the management and operations of this critical global industry - assisted in no small way by maritime informatics.
Building upon the recently published inaugural book Maritime Informatics by Springer, this book will address some of the most recent practical developments and experiences, particularly from a global perspective. The focus of the book is to address contemporary movements to tackle global concerns and to complement Maritime Informatics.
Neurodegenerative diseases of the human brain appear in various forms, resulting in disorders of movement and coordination, cognitive deterioration and psychiatric disturbances. Many of the key factors leading to neurodegenerative diseases are similar, including the dysfunction of metal ion homeostasis, redox-active metal ions generating oxidative stress, and intracellular inclusion bodies. Metal-based Neurodegeneration presents a detailed survey of the molecular origins of neurodegenerative diseases. Each chapter is dedicated to a specific disease, presenting the latest scientific findings, including details of their biochemical actors (proteins or peptides), their normal and pathological conformations, and a description of the diseases characteristics, with an emphasis on the role of metal-induced oxidative stress, which can result in the production of intracellular aggregates of target proteins and peptides. Topics covered include: Brain function, physiology and the blood-brain barrier Immune system and neuroinflammation Aging and mild cognitive impairment, MCI Parkinson's Disease Alzheimer's Disease Creutzfelt-Jakob and related prion diseases Alcoholic Brain Damage Therapeutic strategies to combat the onset and progression of neurological diseases This extensively updated, full colour, second edition of Metal-based Neurodegeneration is an essential text for research scientists and clinicians working in gerontology, neuropathology, neurochemistry, and metalloprotein mechanisms.
This volume analyses maritime decarbonization from various perspectives. It contains unique approaches and tools in four areas: scenarios, value chains, enablers, and partnerships.Decarbonization has become a very important focus in the maritime industry. Anyone that delves into the topic quickly appreciates its breadth and complexity. Minimizing greenhouse gases (GHG) emissions in maritime practices at large and doing it swiftly is far from simple. The Paris 2015 climate goals and the IMO ambitions may be the industry's guiding lights. But is this enough? Probably not. At the managerial level a paradigm shift is needed: from a fixed mindset that is calling for compensation to a growth mindset that seeks to capture the benefits of decarbonization. This will require a structured approach in the form of practical frameworks and clear recommendations. In this book 75 scholars and industry and subject matter experts have joined forces to explore different scenarios, value chain designs, decarbonization enablers, and partnership models to develop frameworks and recommendations around how to effectively work and make progress. The books offers a valuable mix of theory, practical tools, and real-life cases.
